We are seeking an applicant with training and research experience in molecular biology/oncology to carry out an exciting NCI-funded, multidisciplinary project aimed at elucidating the biological effects of proton radiation in cancers. Specifically, we seek to characterize genome wide DNA damage caused by proton radiation and damage responses as a function of tumor genotype. Combinations of protons with targeted drugs will be examined as well. We hope that discovery of biomarkers predicting proton sensitivity will impact the care of cancer patients within the next few years.
Expertise in molecular biology, genomics/bioinformatics, radiation biology, or/and DNA repair is desirable.
Applicants must have a Ph.D. and/or M.D., appropriate research experience, strong organizational, interpersonal, communication, and computer skills and be excited to work in a dynamic team environment.
MGH Jobs Site
We are thankful and honored to have received an award from the MGH Warshaw Institute to establish a high-throughput screening platform for 3-dimensional models of pancreatic cancers. We will test novel combination treatments that include proton radiation. Our work will provide a resource for other investigators and critical preliminary data for future investigations into biologically optimized proton radiation.
Henning Willers, MD & Chris Ott, PhD, Co-PIs
MGH Dept of Radiation Oncology & Center for Cancer Research
We are thrilled to welcome Emily for an in-person lab internship. So nice to be (slowly) getting away from the virtual world we were stuck in for too long. Emily participates in a Summer Program to Advance Research Careers (SPARC), a 12-week intensive research experience focused on emerging technologies in cancer and cancer disparities. She’ll learn about our robotic high-throughput screening project with radiation and targeted drugs!
We offer a position in an exciting, topical, and fast-moving field of translational cancer research. The objective of our studies is to advance precision medicine concepts in the treatment of cancer patients with radiation and specifically proton radiation. The project is centered on whole exome sequencing of tumor tissues from patients and correlative lab studies to characterize the cellular response of genomically characterized tumor cells and tissues to radiation. Collectively the studies will identify predictive biomarkers and mechanisms of enhanced sensitivity of tumors to proton radiation. Techniques include handling of tissues specimens from patients, DNA extraction, mammalian cell culture, PCR, immunofluorescence microscopy, Western blotting, and others. We seek a highly motivated individual with a strong interest in an academic career and prior wet lab experience. The research project is institutionally funded and part of the Radiation Biomarker Research Program in the Department of Radiation Oncology.
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On April 27, 2021, We were thrilled to host our first radiation/cancer biology Grand Rounds speaker, Dr. Julie Schwarz, Professor of Radiation Oncology, Vice Chair of Research, and Director of the Cancer Biology Division at Washington University. She gave an inspiring lecture on using functional imaging and cancer genomics for predicting radiation sensitivity of cervical cancers.
Today we launched a new series -inspired by Science Mondays in the Cancer Center- to focus on radiation science related topics. Great interest on our first Zoom meeting in reviving collaborations in the radiation/immuno-oncology space. Together, we can lift each other up!
We (Li, Clemens & Henning) are very excited to be working toward the Program launch by end of February. Please come back soon to check things out!
Thank you Dave Bjork for having me on your podcast and talking about clinical radiation oncology and the many research opportunities we have to bring precision oncology to our patients with curable lung cancer!
Should have updated this page a long time ago. But in short:
- Proud to have published with Iris Eke, MD PhD, Stanford, a Springer book on molecular targeted radiosensitizers which you can find here .
- We welcomed Aliza Rosenkranz as a research technician to our lab – she will study combining radiation with KRAS G12C inhibition!
- We finally completed our paper studying the replication stress phenotype of KRAS mutant tumor cells, led by co-first authors Tara Al Zubaidi and Fiete Gehrisch. Published by Scientific Reports here.
- Again overhauling our website in preparation for the launch of our Radiation Biology Research Program – stay tuned!