Selected Recent Publications:

  1. Chen H, Zhang J, Wang Y, Simoneau A, Yang H, Levine AS, Zou L, Chen Z, and Lan L. cGAS Suppresses Genomic Instability as a Decelerator of Replication Forks. Science Advances, 2020, Oct 14th: 6, no. 42, eabb8941 PMID: 33055160
  2. Zhang JM, Genois MM, Ouyang J, Lan L, Zou L. Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies. Mol Cell. 2021 Jan 8:S1097-2765(20)30951-5. doi: 10.1016/j.molcel.2020.12.030. Online ahead of print. PMID: 33453166
  3. Chen H, Yang H, Zhu X, Yadav T, J, Zou L, Levine AS, Vasudevan S, Lan L.  m5C Modification of mRNA Serves a DNA Damage Code to Promote Homologous Recombination. Nature Communications. 2020 June 5th. 11, 2834. PMID: 32503981
  4. Tan J, Duan M, Yadav T, Phoon L, Wang X, Zhang JM, Zou L, Lan L. An R-loop-initiated CSB-RAD52-POLD3 pathway suppresses ROS-induced telomeric DNA breaks. Nucleic Acids Res. 2020 Feb 20;48(3):1285-1300. PMID: 31777915 PMCID: PMC7026659
  5. Tan J, Wang X, Hwang BJ, Gonzales R, Konen L, Lan L, Lu AL. An ordered assembly of MYH glycosylase, SIRT6 protein deacetylase, and Rad9-Rad1-Hus1 checkpoint clamp at oxidatively damaged telomeresAging, 2020, Sep 29;12(18):17761-17785.
  6. Tan J, Wang X, Phoon L, Yang H, Lan L. Resolution of ROS-induced G-quadruplexes and R-loops at transcriptionally active sites is dependent on BLM helicase. FEBS Lett. 2020 May;594(9):1359-1367. doi: 10.1002/1873-3468.13738. PMID: 31977077
  7. Teng Y, Yadav T, Duan M, Tan J, Xiang Y, Gao B, Xu J, Liang Z, Liu Y, Nakajima S, Shi Y, Levine AS, Zou L, Lan L. ROS-Induced R Loops Trigger a Transcription-Coupled but BRCA1/2-Independent Homologous Recombination Pathway through CSBNature Communications, 2018 9(1):4115. PubMed PMID: 30297739
  8. Welty S, Teng Y, Liang Z, Zhao W, Sanders LH, Greenamyre JT, Rubio ME, Thathiah A, Kodali R, Wetzel R, Levine AS, Lan L. RAD52 is required for RNA-templated recombination repair in post-mitotic neurons. The Journal of biological chemistry. 2018; 293(4):1353-1362. PubMed [journal] PMID: 29217771, PMCID:PMC5787811
  9. Tan R, Nakajima S, Wang Q, Sun H, Xue J, Wu J, Hellwig S, Zeng X, Yates NA, Smithgall TE, Lei M, Jiang Y, Levine AS, Su B, Lan L. Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1. Molecular cell. 2017; 65(5):818-831.e5. PubMed [journal] PMID: 28216227
  10. Yang L, Sun L, Teng Y, Chen H, Gao Y, Levine AS, Nakajima S, Lan L. Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage. Nucleic acids research. 2017; 45(7):3906-3921. PubMed [journal] PMID: 28160604
  11. Gao Y, Li C, Wei L, Teng Y, Nakajima S, Chen X, Xu J, Leger B, Ma H, Spagnol ST, Wan Y, Dahl KN, Liu Y, Levine AS, Lan L. SSRP1 Cooperates with PARP and XRCC1 to Facilitate Single-Strand DNA Break Repair by Chromatin Priming. Cancer research. 2017; 77(10):2674-2685. NIHMSID: NIHMS863502 PubMed [journal] PMID: 28416484
  12. Sun L, Nakajima S, Teng Y, Chen H, Yang L, Chen X, Gao B, Levine AS, Lan L. WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1. Nucleic acids research. 2017; 45(7):3844-3859. PubMed [journal] PMID: 28158503


Selected Previous Publications:

  1. Lan L, Nakajima S, Oohata Y, Takao M, Okano S, Masutani M, Wilson SH, Yasui A. In situ analysis of repair processes for oxidative DNA damage in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America.  2004; 101(38):13738-43. PubMed [journal] PMID: 15365186
  2. Lan L, Ui A, Nakajima S, Hatakeyama K, Hoshi M, Watanabe R, Janicki SM, Ogiwara H, Kohno T, Kanno S, Yasui A. The ACF1 complex is required for DNA double-strand break repair in human cells. Molecular cell. 2010; 40(6):976-87. PubMed [journal] PMID: 21172662
  3. Lan L, Nakajima S, Wei L, Sun L, Hsieh CL, Sobol RW, Bruchez M, Van Houten B, Yasui A, Levine AS. Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin. Nucleic acids research. 2014; 42(4):2330-45. PubMed [journal] PMID: 24293652
  4. Sun L, Tan R, Xu J, LaFace J, Gao Y, Xiao Y, Attar M, Neumann C, Li GM, Su B, Liu Y, Nakajima S, Levine AS, Lan L. Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death. Nucleic acids research. 2015; 43(13):6334-47. PubMed [journal] PMID: 26082495
  5. Wei L, Nakajima S, Böhm S, Bernstein KA, Shen Z, Tsang M, Levine AS, Lan L. DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination. Proceedings of the National Academy of Sciences of the United States of America. 2015; 112(27):E3495-504. PubMed [journal] PMID: 26100862

Comments are closed.