In collaboration with the Miyamoto Lab, we seek a Postdoctoral Research Fellow for an exciting project aimed at precisely measuring the induction and repair of DNA double-strand breaks across the human genome.
In particular, we are interested in characterizing exogenous double-strand breaks such as those produced by ionizing radiation. To achieve this, the fellow will adapt and implement nucleosome-resolution genomic mapping techniques in human cancer cell lines. Combination treatments with DNA damage response inhibitors may reveal novel therapy approaches that can be translated into patients within a few years. There will also be integration with biophysical modeling of DNA repair and high-throughput screening as part of a multidisciplinary NIH-funded program grant.
A M.D. and/or Ph.D. in oncology, molecular/cellular biology, pathology, or a related field is required. The successful candidate will be highly motivated and a team player with a strong interest in an academic career in cancer research. Applicants should have experience with genomics approaches such as DNA sequencing, library preparation, and bioinformatics analyses.