Selected Papers from Past 5 Years:

Roles of EGFR and KRAS in DNA Repair and Radioresistance:

Wang M, Morsbach F, Sander D, Gheorghiu L, Nanda A, Benes CH, Kriegs M, Krause M, Dikomey E, Baumann M, Dahm-Daphi J, Settleman JE, Willers H. EGF receptor inhibition radiosensitizes NSCLC cells by inducing senescence in cells sustaining DNA double-strand breaks. Cancer Res. 2011 Oct 1;71(19):6261-9

Pfäffle HN, Wang M, Gheorghiu L, Ferraiolo N, Greninger P, Borgmann K, Settleman J, Benes CH, Sequist LV, Zou L, Willers H. EGFR activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity. Cancer Res. 2013, Oct 15;73(20):6254-63

Wang M, Kern AM, Hülskötter M, Greninger P, Singh A, Pan Y, Chowdhury D, Krause M, Baumann M, Benes CH, Efstathiou JA, Settleman J, Willers H. EGFR-mediated chromatin condensation protects KRAS-mutant cancer cells against ionizing radiation. Cancer Res. 2014 May 15;74(10):2825-34

Combinations of Radiation with Targeted Agents:

Liu Q, Wang M, Kern AM, Khaled S, Han J, Yeap BY, Hong TS, Settleman J, Benes CH, Held KD, Efstathiou JA, Willers H. Adapting a Drug Screening Platform to Discover Associations of Molecular Targeted Radiosensitizers with Genomic Biomarkers. Mol Cancer Res. 2015 Apr;13(4):713-20

Coleman CN, Higgins GS, Brown JM, Baumann M, Kirsch DG, Willers H, Prasanna PG, Dewhirst MW, Bernhard EJ, Ahmed MM. Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials. Clin Cancer Res. 2016 Jul 1;22(13):3138-47

Biology of Proton Radiation:

Liu Q, Ghosh P, Magpayo N, Testa M, Tang S, Biggs P, Paganetti H, Efstathiou JA, Lu H-M, Held KD, Willers H. Lung Cancer Cell Line Screen Links Fanconi Anemia/BRCA Pathway Defects to Increased Relative Biological Effectiveness of Proton Radiation. Int J Radiat Oncol Biol Phys 2015 Apr 1;91(5):1081-9

Liu Q, Underwood TS, Kung J, Wang M, Lu HM, Paganetti H, Held KD, Hong TS, Efstathiou JA, Willers H. Disruption of SLX4-MUS81. Function Increases the Relative Biological Effectiveness of Proton Radiation. Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):78-85

Held KD, Kawamura H, Kaminuma T, Paz AE, Yoshida Y, Liu Q, Willers H, Takahashi A. Effects of Charged Particles on Human Tumor Cells. Front Oncol. 2016 Feb 12;6:23

Mechanisms and Biomarkers of DNA Double-Strand Break Repair:

Willers H, Pfäffle HN, Zou L. Targeting Homologous Recombination Repair in Cancer. In: MR Kelley (ed) DNA Repair in Cancer Therapy:  Molecular Targets and Clinical Applications. Academic Press, Elsevier, 2012; pp.119-160

Birkelbach M, Ferraiolo N, Gheorghiu L, Pfäffle HN, Daly B, Ebright MI, Spencer C, O’Hara C,  Whetstine JR, Benes CH, Sequist LV, Zou L, Dahm-Daphi J, Kachnic LA, Willers H. Detection of Impaired Homologous Recombination Repair in NSCLC Cells and Tissues. J Thorac Oncol. 2013 Mar;8(3):279-286.

Xiong X, Du Z, Wang Y, Feng Z, Pan F, Yan C, Willers H, Zhang JR. 53BP1 Promotes Microhomology-Mediated End-Joining In G1-Phase Cells. Nucleic Acids Research 2015 Feb 18;43(3):1659-70

Willers H, Gheorghiu L, Liu Q, Efstathiou, JA, Wirth LJ, Krause M, von Neubeck C. DNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of Radiosensitivity. Semin. Radiat Oncol 2015 Oct;25(4):237-50

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